(2,6-Difluorophenyl)(4-methylpiperidin-1-yl)methanone
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چکیده
In the title compound, C(13)H(15)F(2)NO, the piperidine ring adopts a chair conformation. The dihedral angle between the least-squares plane of the piperidine ring and the benzene ring is 48.75 (7)°. In the crystal structure, the mol-ecules are connected via C-H⋯O hydrogen bonds, forming a zigzag chain along the b axis.
منابع مشابه
(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)(2,6-difluorophenyl)methanone
There are two mol-ecules in the asymmetric unit of the title compound, C(12)H(9)BrF(2)N(2)O. They have very similar conformations: the dihedral angles between their pyrazole and benzene ring systems are 78.4 (3) and 78.6 (4)°. In the crystal, weak aromatic π-π stacking [centroid-centroid separation = 3.696 (5) Å] helps to establish the packing.
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The asymmetric unit of the title compound, C(12)H(9)F(2)N(3)O, contains two independent mol-ecules (A and B) in which the benzene and cyclo-propane rings form dihedral angles of 33.0 (1) and 29.7 (1)°, respectively. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link alternating A and B mol-ecules into chains along [010].
متن کامل(2,3-Difluorophenyl)(4-tosylpiperazin-1-yl)methanone
In the title compound, C(18)H(18)F(2)N(2)O(3)S, the piperazine ring adopts a chair conformation. The dihedral angle between the sulfonyl-bound benzene ring and the best fit plane throught the six non-H atoms of the piperazine ring is 69.4 (2)°, while those between the fluoro-benzene and sulfonyl rings and the fluoro-benzene and piperazine rings are 30.97 (2) and 75.98 (2)°, respectively. In the...
متن کاملCrystal structure of the adduct (4-chlorophenyl)(4-hydroxypiperidin-1-yl)methanone–(4-chlorophenyl)(piperidin-1-yl)methanone (0.75/0.25)
In the title compound, 0.75C12H14ClNO2·0.25C12H14ClNO, which is an adduct comprising 0.75 4-hy-droxy-piperidin-1-yl or 0.25 4-piperidin-1-yl substituents on a common (4-chloro-phen-yl)methanone component; the dihedral angles between the benzene ring and the two piperidine rings are 51.6 (3) and 89.5 (7)°, respectively. The hy-droxy-piperidine ring is in a bis-ectional oriention (bi) with the ph...
متن کاملSynthesis and In Vitro Antimicrobial Activity of 2,4- Difluorophenyl (piperidin-4-yl)methanone Oxime Derivatives
A series of new 2,4-difluorophenyl(piperidin-4-yl)methanone oxime derivatives 4a-h and 5a-e were synthesized by the reaction of 2,4-difluorophenyl(piperidin-4-yl)methanone oxime with various sulfonyl and acid chlorides. The synthesized compounds were characterized by elemental analyses, FTIR, 1 H NMR and LCMS spectral studies. All compounds were evaluated for in vitro antibacterial and antifung...
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